Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 3;176(2):343–354. doi: 10.1093/toxsci/kfaa081

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by Oxford University Press on behalf of the Society of Toxicology 2020. This work is written by US Government employees and is in the public domain in the US.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Figure 6. — Lowest transcriptional (liver or kidney) versus apical (non-neoplastic or neoplastic) benchmark doses (BMDs) independent of sex and species. The fold difference of the lowest transcriptional Gene Ontology Biological Process (GO BP) BMD (liver or kidney) in male rats and the overall lowest apical (non-neoplastic or neoplastic) BMD in male or female rats or mice is shown. A negative fold difference indicates that the liver or kidney GO BP BMD is less than the apical (non-neoplastic or neoplastic) BMD. A positive fold difference indicates that the liver or kidney GO BP BMD is greater than the apical (non-neoplastic or neoplastic) BMD. The solid line represents no difference, whereas the dotted lines represent a 10-fold difference between the liver or kidney GO BP BMD and the apical (non-neoplastic or neoplastic) BMD. HT indicates hepatotoxic chemicals. Non-HT indicates chemicals that exhibit minimal/no hepatotoxicity but produce adverse effects in other tissues. Neg indicates chemicals that exhibit little overt toxicity to the liver or other tissues. Male rats (MR), female rats (FR), male mice (MM), or female mice (FM) indicate which sex and species the overall lowest apical (non-neoplastic or neoplastic) BMD was observed in for each of the chemicals shown.