Table 3.
Chronic or Subchronic Toxicity Studies for Selected Chemicals
| Chemical | Study Type | Hepatotoxic | Rat Strain | Route/Vehicle | Concentrations Tested a |
|---|---|---|---|---|---|
| ACR | 2-year (NTP TR 575) | No (otherb) | F344/N | Drinking water | 0, 0.33, 0.66, 1.32, 2.71 |
| BDCA | 2-year (NTP TR 583) | No (other) | F344/NTac | Drinking water | 0, 11, 21, 43 |
| COU | 2-year (NTP TR 422) | Yes | F344/N | Gavage/corn oil | 0, 25, 50, 100 |
| DEHP | 2-year (NTP TR 217) | Yes | F344 | Feed/NA | 0, 322, 674 |
| DE71 | 2-year (NTP TR 589) | Yes | Wistar Han | Gavage/corn oil | 0, 3, 15, 50 |
| EE2 | 2-year (NTP TR 548) | No (other) | NCTR SD (F1C) | Feed/NA | 0, 0.15, 0.6, 3.3 |
| FEN | 29-day (TG-GATEs)c | Yes | Sprague Dawley | Gavage/0.5% aqueous methylcellulosed | 0, 10, 100, 1000 |
| FUR | 2-year (Von Tungeln et al., 2017) | Yes | F344/N | Gavage/corn oil | 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92, 2 |
| 2-year (NTP TR 402)e | Yes | F344/N | Gavage/corn oil | 0, 2, 4, 8 | |
| GIN | 2-year (NTP TR 567) | No | F344/N | Gavage/deionized water | 0, 1250, 2500, 5000 |
| HCB | 2-year (Arnold et al., 1985) | Yes | Sprague Dawley | Feed/NA | 0, 0.02, 0.09, 0.47, 2.35 |
| MET | 2-year (NTP TR 491) | Yes | F344/N | Gavage/0.5% aqueous methylcellulose | 0, 37, 75, 150, 300 |
| MTE | 2-year (NTP TR 565) | No | F344/N | Feed/NA | 0, 570, 1180, 2520 |
| PFOA | 2-year (NTP TR 598) | Yes | Sprague Dawley | Feed/NA | 0, 2.2, 4.4, 8.8 |
| PUL | 2-year (NTP TR 563) | Yes | F344/N | Gavage/corn oil | 0, 18.75, 37.5, 75 |
| TBBPA | 2-year (NTP TR 587) | No (other) | Wistar Han | Gavage/corn oil | 0, 250, 500, 1000 |
| TCAB | 2-year (NTP TR 558) | Yes | Sprague Dawley | Gavage/corn oil: acetone (99:1) | 0, 10, 30, 100 |
| TCPP | 90-day (NTP TOX)f | Yes | B6C3F1g | Feed/NA | 0, 250, 500, 1000, 2000, 4000 |
| THU | 2-year (NTP TR 570) | No (other) | F344/N | Gavage/0.5% aqueous methylcellulose | 0, 12.5, 25, 50 |
a
mg/kg Except ethinyl estradiol (µg/kg).
b
Not hepatotoxic but toxic to other tissues.
c
TG-GATES (https://toxico.nibiohn.go.jp/english).
d
In deionized water.
e
Apical data used only for female rats and male and female mice.
f
Report in-progress (unpublished data).
g
Data shown for mice only.
Abbreviation: NA, not applicable.