Figure 7.
Subtoxic Mn exposure does not substantially affect mitochondrial substrate dependence. (A) STHdhQ7/Q7 and (B) STHdhQ111/Q111 basal, leak, and maximum mitochondrial oxygen consumption rates (OCR) (pmol/min). Left, vehicle-treated cultures, right, cultures treated with 50 µM Mn 24 h prior to assay. Compounds added to inhibit substrate utilization during the course of the assay are indicated below respective bars. Results combined from 3 independent experiments, n = 3–5; total n = 10. Error bars reflect SEM. *p < .05, **p < .01, ***p < .001, by Dunnett’s test relative to control for each measurement.