Figure 5.

Gene set enrichment analysis on cluster-specific gene expression differences with Pb exposure in the hippocampus. In clusters 0–3, 5, and 7–9, gene ontologies were identified with FDR < 0.05 and these ontologies contained genes that were largely unique (A). In panels (B) and (C), genes within a cluster are shown on the x-axis, ranked by their magnitude of association with Pb exposure and painted by the level of significance of their association with Pb exposure. In cluster 1, the protein folding pathway was upregulated (GO:0006457) (B). In cluster 2, the interleukin 12 biosynthetic process pathway was upregulated (GO:0006950) (C). In cluster 7, double-strand break repair via nonhomologous end joining pathway was downregulated (GO:0006303) (D).