Table 1.
Cluster | Number of Cells | Predicted Identity | Top Marker Genes | Ctrl % | Pb % | p Value |
---|---|---|---|---|---|---|
0 | 1329 | Endothelial | Itm2a, Cldn5, Slco1a4 | 26.85 | 24.56 | .67 |
1 | 1303 | Microglia | Hexb, C1qc, Ctss | 26.61 | 23.95 | .15a |
2 | 1192 | Oligodendrocytes | Plp1, Aplp1, Cldn11 | 14.58 | 26.36 | .0002a |
3 | 356 | Pericytes | Myl9, Rgs5, Tagln | 7.23 | 6.56 | .66a |
4 | 306 | Astrocytes | Aldoc, Slc1a3, Slc1a2 | 5.59 | 5.92 | .85 |
5 | 181 | Oligodendrocyte progenitor | Pdgfra, Clql1, Matn4 | 2.49 | 3.88 | .04 |
6 | 129 | Choroid plexus | Kl, Igfbp2, 1500015O10Rik | 4.19 | 1.66 | .82 |
7 | 115 | Pericytes | Ndufa4l2, Ifitm1, Rgs4 | 1.88 | 2.33 | a |
8 | 109 | Neurons | Reln, Snhg11, Ndnf | 2.19 | 2.02 | .96 |
9 | 101 | Microglia | H2-Eb1, H2-Aa, H2-Ab1 | 2.25 | 1.77 | a |
10 | 93 | Oligodendrocytes | Ptprd, Ttll7, Ermn | 5.35 | 0.14 | a |
11 | 44 | Fibroblasts | Dcn, Spp1, Slc7a11 | 0.79 | 0.86 | .14 |
Microglia (1 and 9), oligodendrocyte (2 and 10), and pericyte (3 and 7) clusters were collapsed when testing for differences in proportions by Pb exposure.