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. 2020 May 27;176(2):396–409. doi: 10.1093/toxsci/kfaa069

Table 1.

Number of Cells Observed per Cluster and the Predicted Cell Type Identity of That Cluster

Cluster Number of Cells Predicted Identity Top Marker Genes Ctrl % Pb % p Value
0 1329 Endothelial Itm2a, Cldn5, Slco1a4 26.85 24.56 .67
1 1303 Microglia Hexb, C1qc, Ctss 26.61 23.95 .15a
2 1192 Oligodendrocytes Plp1, Aplp1, Cldn11 14.58 26.36 .0002a
3 356 Pericytes Myl9, Rgs5, Tagln 7.23 6.56 .66a
4 306 Astrocytes Aldoc, Slc1a3, Slc1a2 5.59 5.92 .85
5 181 Oligodendrocyte progenitor Pdgfra, Clql1, Matn4 2.49 3.88 .04
6 129 Choroid plexus Kl, Igfbp2, 1500015O10Rik 4.19 1.66 .82
7 115 Pericytes Ndufa4l2, Ifitm1, Rgs4 1.88 2.33 a
8 109 Neurons Reln, Snhg11, Ndnf 2.19 2.02 .96
9 101 Microglia H2-Eb1, H2-Aa, H2-Ab1 2.25 1.77 a
10 93 Oligodendrocytes Ptprd, Ttll7, Ermn 5.35 0.14 a
11 44 Fibroblasts Dcn, Spp1, Slc7a11 0.79 0.86 .14
a

Microglia (1 and 9), oligodendrocyte (2 and 10), and pericyte (3 and 7) clusters were collapsed when testing for differences in proportions by Pb exposure.