Table 1.
Overall Arsenic Effect on Pathway-level Gene Expression
| Hallmark Gene Set | No. of Genes in Dataset | Direction | FDR |
|---|---|---|---|
| E2F_TARGETS | 140 | Down | 5.31E−05 |
| CHOLESTEROL_HOMEOSTASIS | 54 | Up | 0.000326084 |
| MYC_TARGETS_V1 | 193 | Down | 0.008222994 |
| IL6_JAK_STAT3_SIGNALING | 71 | Up | 0.009576791 |
| XENOBIOTIC_METABOLISM | 111 | Up | 0.009576791 |
| TNFA_SIGNALING_VIA_NFKB | 168 | Up | 0.009576791 |
| COAGULATION | 63 | Up | 0.013944503 |
| ADIPOGENESIS | 147 | Up | 0.014601948 |
| ANGIOGENESIS | 18 | Up | 0.025714191 |
| HYPOXIA | 124 | Up | 0.029940812 |
| SPERMATOGENESIS | 43 | Down | 0.037158419 |
| BILE_ACID_METABOLISM | 46 | Up | 0.037158419 |
| MYC_TARGETS_V2 | 52 | Down | 0.037158419 |
| G2M_CHECKPOINT | 133 | Down | 0.037158419 |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 66 | Up | 0.037927805 |
| MYOGENESIS | 64 | Up | 0.041120419 |
| PROTEIN_SECRETION | 84 | Up | 0.050861297 |
Hallmark gene sets that were differentially expressed (FDR-corrected p < .1) are listed, along with the number of genes on the pathway in the dataset, the overall direction of regulation, and the FDR-corrected p value.
Abbreviation: FDR, false discovery rate.