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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: Nat Biomed Eng. 2020 Apr 6;4(4):381–393. doi: 10.1038/s41551-020-0525-x

Table 1.

Major technological advancements in reproductive science and medicine

Year Advancement References
1895 First ovarian graft transplantation 1
1931 First human uterus transplantation 2
1936 First modern penile implant 3
1941 First testis prosthesis 4
1978 First human birth from IVF
First human testis transplantation
5
6
1984 Human birth from frozen embryo 7
1986 Successful cryopreservation of human oocytes 8
1992 IVF by intracytoplasmic sperm injection 9
2004 Human birth from ovarian tissue transplantation
Human whole ovary transplantation
10
11
2006 Cryopreservation of whole human ovary
Oncofertility field established
Live animal birth from follicles grown in vitro within a biomaterial
12
13
14
2014 Engineered vagina transplant 15
2015 Human metaphase-II oocyte in vitro
Human birth from uterus transplantation
16
17
2017 EVATAR
Biobag
Functional 3D-printed ovarian bioprosthetic
18
19
20

Table 1 displays current trends in engineering reproductive tissues evolved from scientific and technological developments aimed to improve reproductive-health outcomes.