Skip to main content
. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2020 Aug;76(2):164–172. doi: 10.1097/FJC.0000000000000855

Figure 5. NS8593 (10 μM) prevents the induction of acetylcholine (ACh) - mediated atrial fibrillation largely by depressing excitability.

Figure 5.

Shown are action potential tracings. A: Rapid pacing induced AF in the presence of ACh alone. B: Rapid pacing fails to induce AF in the presence of NS8593 and ACh due to significant rate-dependent depression of excitability, manifested as a failure of 1:1 activation.