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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2020 Aug;76(2):164–172. doi: 10.1097/FJC.0000000000000855

Figure 6. UCL1684 and NS8593 produce direct atrial-selective inhibition of sodium channel current (INa) and shift steady-state inactivation of the cardiac sodium channels.

Figure 6.

A: Representative INa recordings from a NaV1.5-WT plus NavB1-WT expressed in HEK cells in presence of UCL1684. B: Effect of NS8593 (10 μM) effect on sodium channel current density at test potential of −20 mV in canine atrial and ventricular myocytes recorded at holding potentials (HP) of −120 mV and −90 mV. C. Effect of NS8593 (10 μM) on steady-state inactivation of the sodium channels in atrial and ventricular cardiac myocytes.