. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Pediatr Crit Care Med. 2020 Aug;21(8):708–719. doi: 10.1097/PCC.0000000000002310

Table 2.

Ventilation and gas exchange at inhaled nitric oxide initiation with Day 28 mortality

	Day 28 mortality
	Dead (N = 45) [Q1, Median, Q3]	Alive (N = 106) [Q1, Median, Q3]	P-value
Ventilation type^1,2			0.372²
Conventional	37/133 (27.8%)	96/133 (72.2%)
HFOV	6/15 (40.0%)	9/15 (60.0%)
NA	2/3 (66.7%)	1/3 (33.3%)
PaO2 (mmHg)	n=34 [55.0, 67.0, 82.0]	n=71 [54.1, 64.0, 78.3]	0.742³
SpO₂ (%)	n=42 [89.0, 92.5, 96.0]	n=103 [90.0, 94.0, 97.0]	0.297³
Exhaled tidal volume (mL/kg)	n=25 [6.6, 7.5, 8.9]	n=75 [6.5, 7.9, 9.4]	0.535³
MAP (cmH₂O)	n=35 [16.0, 21.0, 30.1]	n=91 [14.0, 18.0, 22.0]	0.035³
FiO₂	n=44 [0.7, 0.9, 1.0]	n=106 [0.7, 0.9, 1.0]	0.743³
PEEP (cmH₂O)	n=37 [6.0, 12.0, 14.0]	n=95 [8.0, 10.0, 12.0]	0.352³
PIP (cmH₂O)	n=34 [31.0, 33.0, 38.0]	n=91 [27.0, 32.0, 36.0]	0.113³
ETCO₂ (mmHg)	n=27 [27.0, 35.0, 48.0]	n=64 [31.5, 41.0, 54.0]	0.099³
Oxygenation index	n=26 [16.1, 24.0, 39.1]	n=60 [13.9, 20.8, 31.8]	0.489³
Oxygenation saturation index	n=28 [12.8, 19.3, 25.0]	n=70 [12.7, 16.6, 22.0]	0.269³
Time between iNO initiation and mechanical ventilation initiation (hours)	n=41 [5.5, 45.2, 128.2]	n=100 [6.7, 29.9, 82.7]	0.325³

If a parameter value was not entered at inhaled nitric oxide initiation, the closest prior value to initiation was used. Ventilation parameters up to 6 hours prior to iNO initiation were considered.

Row percentages are reported.

Fisher's exact test was used to compare mortality between conventional and HFOV ventilation modes. 1 subject was started on mechanical ventilation after iNO initiation and 2 subjects did not have ventilation type recorded at time of iNO initiation. Reported as NA.

Wilcoxon rank-sum test.