Table 5.
Outcomes associated with clinician response to oxygenation improvement*
| Clinician response | ||||
|---|---|---|---|---|
| None or delayed (N = 36) |
Timely (N = 92) |
Unable to determine (N = 2) |
P-value | |
| ECMO after Day 0 | 2 (5.6%) | 16 (17.4%) | 0 (0%) | 0.0973 |
| Days on mechanical ventilation | 18.0 [12.0, 31.0] | 13.0 [9.0, 21.0] | 2.5 [2.0, 3.0] | 0.0214 |
| Ventilator-free days | 4.0 [0.0, 13.0] | 11.0 [0.0, 18.0] | 0.0 [0.0, 0.0] | 0.0224 |
| Cardiac arrest on Day 0 | 2 (5.6%) | 8 (8.7%) | 1 (50.0%) | 0.7243 |
| Cardiac arrest after Day 0 | 4 (11.1%) | 8 (8.7%) | 1 (50.0%) | 0.7393 |
| CVVH/dialysis after Day 0 | 7 (19.4%) | 12 (13.0%) | 0 (0%) | 0.4103 |
| ICU length of stay (days)1 | 23.0 [12.0, 45.0] | 20.0 [12.0, 36.0] | 1.5 [1.0, 2.0] | 0.6184 |
| Hospital length of stay (days)1 | 28.5 [17.5, 52.5] | 30.5 [19.5, 58.5] | 1.5 [1.0, 2.0] | 0.4414 |
| Day 28 mortality | 1.0003 | |||
| Dead | 8 (22.2%) | 21 (22.8%) | 2 (100.0%) | |
| Alive | 28 (77.8%) | 71 (77.2%) | 0 (0%) | |
| Survivors | ||||
| Total | 28 | 71 | 0 | |
| New morbidity2 | 0.1083 | |||
| No | 19 (67.9%) | 59 (83.1%) | 0 (0%) | |
| Yes | 9 (32.1%) | 12 (16.9%) | 0 (0%) | |
Table includes subjects whose oxygenation improved on iNO. Oxygenation improvement defined as either an SpO2 greater than 88% or a PaO2 greater than 60 mmHg within 24 hours of iNO initiation.
Five subjects were still in the hospital at study end. Two of the five were still in the ICU. Hospital and ICU length of stay for these subjects were truncated between 8-15 months and 8-10 months respectively.
A new morbidity was defined as an increase (worsening) in the Functional Status Scale (FSS) by three or more from baseline to ICU discharge or Day 28.
Fisher's exact test.
Wilcoxon rank-sum test.
ECMO - Extracorporeal membrane oxygenation
CVVH - Continuous veno-venous hemofiltration
ICU - Intensive care unit