The proportion of patients within each burden group during the epoch with maximum daily burden is compared between patients with poor versus good outcome. Patients with poor outcomes tend to have higher maximum daily burden. After adjusting for covariates (age, gender, APACHE II, NIHSS, stroke treatment, cortical location, temporal vs. extratemporal stroke, anterior vs. posterior circulation, hemorrhagic transformation, CCI, history of epilepsy) we found that increasing maximum daily burden was associated with worse discharge outcome (OR 1.89 [1.18–3.03] p = 0.009).