Table 2:
MRI imaging features and their association with pathologic complete response (pCR) (n=51). BPE = background parenchymal enhancement, IER = initial enhancement ratio, NME = nonmass enhancement.
| Pathologic complete response (pCR) | |||
|---|---|---|---|
| Yes | No | P-value | |
| Concentric shrinkage | 0.000 | ||
| Yes | 28/37 (75.7%) | 9/37 (24.3%) | |
| No | 1/14 (7.1%) | 13/14 (92.9%) | |
| Imaging response** | 0.073 | ||
| Yes | 28/45 (62.2%) | 17/45 (37.8%) | |
| No | 1/6 (16.7%) | 5/6 (83.3%) | |
| Lesion type | 0.726 | ||
| Mass | 24/43 (55.8%) | 19/43 (44.2%) | |
| NME | 3/8 (37.5%) | 5/8 (62.5%) | |
| Lesion shape (masses only+) | 0.403 | ||
| Oval/round | 7/11 (63.6%) | 4/11 (36.4%) | |
| Irregular | 17/32 (53.1%) | 15/32 (46.9%) | |
| BPE | 0.780 | ||
| Minimal to mild | 16/29 (55.2%) | (13/29) 44.8% | |
| Moderate to marked | 13/22 (59.1%) | 9/22 (40.9%) | |
| Positive axillary nodes | 0.066 | ||
| Yes | 18/37 (48.6%) | 19/37 (51.4%) | |
| No | 11/14 (78.6%) | 3/14 (21.4%) | |
| Size (average, range) | 4.45 cm (1.3–11.0 cm) | 3.93 (1.2–8.3 cm) | 0.315 |
| ki-67% (average, range) | 54.7% (20–95%) | 40.94% (0–90%) | 0.121 |
| IER | |||
| Reader 1 | 271.83% (145–375%) | 279.12% (133–405%) | 0.665 |
| Reader 2 | 284.22% (102–416%) | 271.0% (113–379%) | 0.766 |
**
defined by RECIST 2.0 criteria
+
Insufficient numbers for NME subgroup analysis