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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Acta Biomater. 2020 May 17;112:149–163. doi: 10.1016/j.actbio.2020.05.009

Fig 8.

Fig 8.

CD4 T cells and IL-4 are critical to early myelination of axons within ANAs. WT mice sciatic nerve were repaired using ANA and treated with antibodies to deplete CD4 T cells or neutralize IL-4 up to the 14 day endpoint. A&B) Representative immunofluorescence and quantification of myelin (MBP, red), neurofilament (NF200, green), and Schwann cells (S100, green) within ANAs for CD4 depletion groups. C&D) Representative immunofluorescence and quantification of myelin (MBP, red), neurofilament (NF200, green), and Schwann cells (S100, green) within ANAs for IL-4 neutralization groups. Mean ± SD, n=5/group; p values shown. Scale bar represent 50 μm.