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. 2020 Aug 3;7:186. doi: 10.3389/fmolb.2020.00186

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Copyright © 2020 Pirone, Del Gatto, Di Gaetano, Saviano, Capasso, Zaccaro and Pedone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequences alignment by Clustal omega (https://www.ebi.ac.uk/Tools/msa/clustalo/). (1) CRD from human Galectin 3 – BAA22164 Genebank; (2) SARS CoV-2 NTD_{103aa–314aa} PDB:6VSB; (3) BCoV NTD_{116aa–305aa} PDB: 4H14. The ganglioside domain in SARS CoV-2 NTD is in cyan (Fantini et al., 2020). The residues critical for sugar-binding are reported in bold (as shown in Peng et al., 2012 regarding BCoV sugar binding site). The conserved cysteine residues between SARS CoV-2 and BCoV NTD are shown in yellow.