Table 4.

Bedaquiline minimum inhibitory concentrations of 21 isolates tested on 7H11 agar with the 1% proportion method, showing number of isolates that have genetically wild-type Rv0678 and those with Rv0678 variants

		<0·03 μg/mL	0·03 μg/mL	0·06 μg/mL	0·12 μg/mL	0·25 μg/mL	0·5 μg/mL	1·0 μg/mL
H37Rv		..	1	2	..	..	..	..
Clinical isolates
	Wild type	2	2	3	..	..	..	..
	Val1Ala/Gly37fs/Arg89Trp	..	..	..	..	1	..	..
	Val20Gly	..	..	..	..	1	..	..
	Gln22Pro/Asp47fs	..	..	..	..	..	1*	1
	Cys46fs	..	..	..	..	..	..	1
	Cys46fs/Asp47fs	..	..	..	..	..	..	2
	Asp47fs	..	..	..	..	..	2	..
	Asp47fs/Ile67fs/Leu136Arg	..	..	..	..	..	..	1
	Glu49fs	..	1	..	..	1	..	..
	Ile67fs	..	..	..	..	1	1	..
	Phe93Leu	..	..	..	1	..	..	..
	Phe93Ser	..	..	..	..	2	..	..
	Arg109Leu/Arg156fs	..	..	..	..	2	..	..
	Ala118Thr	..	..	..	1	..	..	..
	Glu147fs	..	..	..	..	1	..	..

Mycobacterium tuberculosis strain H37Rv was included in each batch for quality control.

^*This isolate had an additional six Rv0678 mutations below 15% allele frequency.