TABLE II. Selection of Bartonella bacilliformis USM-LMMB07 proteins by incorporating centrality, chokepoint and drug binding filters.

Locus tag	Gene	Gene product	DS	Human off target	Gut microb	C	Chk	DB	PB
AWH67_RS01355	rdgB	non-canonical purine NTP pyrophosphatase	0.93	0.72	1	0.97	True	False	False
AWH67_RS04105	folA	dihydrofolate reductase	0.97	0.68	21	0.96	True	True	True
AWH67_RS00185	maf2	septum formation protein	0.85	0.64	12	0.97	True	False	False
AWH67_RS04665	purB	adenylosuccinate lyase	0.86	0.73	51	0.77	True	False	False
AWH67_RS05475	-------	beta-ketoacyl-ACP synthase II	0.97	1	0	0.21	True	False	False
AWH67_RS03970	murE	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase	0.95	1	0	0.2	True	True	True
AWH67_RS05335	fabZ	beta-hydroxyacyl-ACP dehydratase	0.92	1	22	0.19	True	False	False
AWH67_RS05565	fabH	3-oxoacyl-ACP synthase III	0.89	1	67	0.21	True	False	False
AWH67_RS01510	aroA	3-phosphoshikimate 1-carboxyvinyltransferase	0.78	1	23	0.27	True	True	True
AWH67_RS02160	trmFO	FADH(2)-oxidising methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	0.75	1	72	0.2	True	True	True
AWH67_RS02410	uppP	undecaprenyl-diphosphatase	0.74	1	3	0.12	True	True	True
AWH67_RS03995	murG	undecaprenyl diphosphate-muramoylpentapeptide beta-N- acetylglucosaminyltransferase	0.73	1	0	0.12	True	False	False
AWH67_RS01650	fabI	enoyl-(acyl-carrier-protein) reductase	0.99	0.71	16	0.1	True	True	True
AWH67_RS04685	purQ	phosphoribosylformylglycinamidine synthase subunit	0.89	0.75	40	0.1	True	False	False
AWH67_RS01345	dapE	succinyl-diaminopimelate desuccinylase	0.75	0.78	11	0.2	True	False	False
AWH67_RS04690	purL	phosphoribosylformylglycinamidine synthase subunit	0.79	0.77	39	0.1	True	False	False
AWH67_RS02870	fabI	enoyl-(acyl-carrier-protein) reductase	0.77	0.73	16	0.1	True	False	False

C: centrality; Chk: chokepoint; DB: drug binding; DS: druggability score; PB: pocket with binding. -Best candidate proteins are highlighted in yellow.