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. 2020 Jul 31;11:489. doi: 10.3389/fendo.2020.00489

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Copyright © 2020 Tonelli, Bek, Besio, De Clercq, Leoni, Salmon, Coucke, Willaert and Forlino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Advantages of the zebrafish model. Zebrafish has several advantages compared to mammal models. High fecundity and external fertilization and development allow easy genomic manipulation, transparent early life stages guarantee in vivo imaging and skin permeability makes them suitable for high throughput drug screening (top). Adult zebrafish reaches a maximum size of 3–4 cm and this make it easy and cheap to keep it in large numbers, reducing the husbandry cost (bottom left). Finally, zebrafish is used as a vertebrate model to study regeneration, due to its ability to regenerate different organs, such as the caudal fin, which is completely regenerated 14 days post amputation (bottom right). hpf, hours post fertilization.