Model Parameters | Value | Source |
---|---|---|
Y (Young’s modulus) | 1 | Normalized in simulation units |
v (Poisson ratio) | 0.5 | Assumption of cell incompressibility (Heer et al., 2017) |
h (Tissue thickness) | 1 | Normalized in simulation units |
x0 (Contractile region length along AP axis) | 20 | Consistent with experimentally observed myosin gradients (Heer et al., 2017) |
k (Contractility gradient steepness) | 0.5 | Consistent with experimentally observed myosin gradients (Heer et al., 2017) |
y0 (Contractile region length perpendicular to AP axis) | 4 | Consistent with experimentally observed myosin gradients (Heer et al., 2017) |
M0 (Maximum contractility) | 5 (Fig 6B) 3-5 (Fig 6C) |
Contractility parameter chosen to produce appropriate furrow morphology (Heer et al., 2017) |
kmax (EDGE STIFFNESS) | 10 | Based on difficulty quantifying edge stiffness in vivo, defaulted to a factor of ten stiffer than surrounding tissue |
σ (Network edge thickness) | 0.25 | Edge thickness chosen to be small relative to mean edge length and cell width |
μv (Internal compressibility) | 0.0001 | Parameter value chosen to ensure volume conservation (Heer et al., 2017) |
μs (External shell stiffness) | 200 | Parameter value chosen to ensure small penetration of containing shell (Heer et al., 2017) |
y1 (Contractile region length perpendicular to AP axis in Spn27A Mutant) | 7.5 | Consistent with experimentally observed myosin gradients (Heer et al., 2017) |
kx (Gradient along AP Axis for SP) | 0.15 | Shallow gradient along AP axis consistent with experimental measurements (Streichan et al., 2018) |