FIGURE 3.
Manhattan plot showing the results of the epigenome‐wide association study (EWAS) meta‐analysis of the CAIDE1 dementia risk score and the positions of differentially methylated regions (DMRs) identified in a meta‐DMR analysis. Each point represents one of the 772,453 loci included in the EWAS meta‐analysis, with the point's position being determined by genomic position (x‐axis) and significance in the EWAS meta‐analysis (–log10 P value; y‐axis). Sites attaining genome‐wide significance (P ≤ 3.6 × 10−8) are indicated in red and those that are involved in a significant DMR (Bonferroni‐correct P ≤ .05) are indicated in blue. The locations of DMRs are further indicated by vertical blue lines. The solid horizontal line is the threshold for genome‐wide significance (P ≤ 3.6 × 10−8) and the dashed line indicates a suggestive significance threshold (P ≤ 1 × 10−5)