TABLE 1.

Top 20 DMPs associated with the AD GRS in a meta‐analysis of the discovery and replication samples

ID	Chr.	BP a	Gene symbol	Effect	SE	P
cg10757760	2	127893054		0.0568	0.0039	6.15 × 10−48
cg04441687	11	85869322		0.0586	0.0041	1.12 × 10−46
cg26631131	19	45240591		0.0385	0.0029	1.56 × 10−39
cg02887598	2	127841945	BIN1	−0.0986	0.0085	2.51 × 10−31
cg19116668	7	99932089	PMS2L1	0.049	0.0051	1.54 × 10−21
cg18959616	11	85814918		0.0656	0.0072	5.85 × 10−20
cg02521229	11	60019236		0.0658	0.0073	1.61 × 10−19
cg03579757	7	100091793	NYAP1	0.0342	0.0038	2.33 × 10−19
cg16618979	7	143108841	AC092214.10	0.0974	0.0109	5.11 × 10−19
cg03526776	6	41159608	TREML2	−0.0402	0.0045	7.06 × 10−19
cg11461311	2	127782614	RP11‐521O16.1;RP11‐521O16.2	0.0321	0.0036	1.31 × 10−18
cg00436254	2	127862614	BIN1	0.0256	0.003	6.76 × 10−18
cg06750524	19	45409955	APOE	0.05	0.0059	2.18 × 10−17
cg23423086	11	85856245		−0.0365	0.0043	2.37 × 10−17
cg22906224	7	99728672	AC073842.19	−0.0392	0.0047	3.55 × 10−17
cg05908241	7	143109367	AC092214.10	0.0283	0.0035	6.62 × 10−16
cg17830204	7	99819110	GATS;PVRIG;STAG3;AC005071.1	0.0308	0.0039	4.78 × 10−15
cg19590598	2	127782813	RP11‐521O16.1;RP11‐521O16.2	0.0282	0.0036	5.22 × 10−15
cg08871934	10	11720283		−0.0343	0.0044	9.59 × 10−15
cg09555818	19	45449301	APOC2;APOC4	−0.0498	0.0065	1.24 × 10−14

Abbreviations: BP, base position; Chr., chromosome; SE, standard error, DMP; differentially methylated position; GRS, genetic risk score.

^aBase position in genome assembly hg19/GRCh37.