Fig. 1.

Hemispheric brain regions (left and right hemisphere, medial/limbic regions) associated with different measures of disinhibition in patients with neurodegenerative diseases. In red, atrophied regions associated with disinhibition, as such left and right orbitofrontal cortex, right inferior and middle frontal cortex, right inferior, middle and superior gyri, temporal pole and subgenual cingulate. In blue, regions showing different functional activity in disinhibited patients, as such the right angular cortex and prefrontal cortex. In yellow, regions found to show metabolic differences in disinhibited patients, as such posterior orbitofrontal cortex, medial frontal cortex and limbic structures including the hippocampus, amygdala, caudate, nucleus accumbens and insula (insula not shown here). In violet, overlapping regions involved in both structural and functional studies, such as the right lateral prefrontal cortex and left inferior frontopolar regions.