. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Eur J Nutr. 2019 Sep 18;59(6):2369–2381. doi: 10.1007/s00394-019-02085-3

Table 2.

Results of multiple regression models of effect of treatment with isoflavones on systolic and diastolic blood pressure in 197 premenopausal women assessed by intention-to-treat analysis

		Systolic Blood Pressure ^*		Diastolic Blood Pressure ^*
	Effect	β-Estimate (SE)	P value	β-Estimate (SE)	P value
Model 1^†	Treatment×Month	−0.040 (0.071)	0.57	0.023 (0.041)	0.57
Model 2^‡	Treatment×Month	−0.036 (0.071)	0.61	0.029 (0.041)	0.48
Model 2^‡	Calcium	0.869 (0.856)	0.31	0.787 (0.539)	0.15
Model 3^§	Treatment×Month	−0.018 (0.071)	0.80	0.030 (0.041)	0.46
	Calcium	2.494 (1.278)	0.051	0.936 (0.797)	0.24
	Treatment×Calcium	−2.943 (1.719)	0.09	−0.274 (1.082)	0.80
Model 4^‖	Treatment×Month	−0.023 (0.070)	0.75	0.024 (0.041)	0.56
	Calcium	2.740 (1.258)	0.030	1.051 (0.791)	0.18
	Treatment×Calcium	−2.779 (1.695)	0.10	−0.221 (1.073)	0.84

Regression coefficient (β-Estimate), corresponding standard error (SE), and P value for effect indicated.

^†

Model 1 included treatment (Treatment), number of months on treatment (Month), and the interaction term of Treatment×Month measured at each sampling.

^‡

Model 2 included the variables in model 1 and mean-centered calcium.

^§

Model 3 included the variables in model 2 and the interaction term of Treatment×Calcium. Consult results of Tables 3–4 for rationale for testing Treatment×Calcium.

^‖

Model 4 included the variables in model 3 and age at entry to the study, race, and BMI measured at the time of each blood sampling.