. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Eur J Nutr. 2019 Sep 18;59(6):2369–2381. doi: 10.1007/s00394-019-02085-3

Table 5.

Estimated intervention effects of isoflavones conditioned on serum calcium levels on systolic blood pressure during treatment of women with isoflavones using amounts of genistein excreted in urine, as an example

	Effects on systolic blood pressure (mmHg)^*
Genistein (GE), mg/h (percentile)	Calcium, mg/dL (percentile)
Genistein (GE), mg/h (percentile)	1.46 (100^th)	0.56 (90^th)	−0.05 (50^th)	−0.45 (10^th)	−1.15 (0^th)
0.77 (100^th)	−13.07	−5.06	0.37	3.93	10.16
0.22 (90^th)	−2.69	−1.05	0.07	0.80	2.08
−0.06 (50^th)	2.59	1.00	−0.08	−0.79	−2.03
−0.14 (10^th)	4.10	1.58	−0.13	−1.25	−3.21
−0.17 (0^th)	4.67	1.80	−0.14	−1.42	−3.65
Intervention effect^†	−17.74	−6.86	0.51	5.35	13.81

Estimated using regression coefficients of genistein excretion (GE) as a predictor in Model 3 (Table 4); consult footnote of Table 3 for means used to center GE and calcium.

^†

Comparing between excreting maximum and minimum GE.