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. 2020 Aug 10;104(5):807–825. doi: 10.1016/j.mcna.2020.06.007

Table 3.

Abbreviated diagnostic criteria for commonly diagnosed neurodegenerative dementias

Diagnosis Abbreviated Diagnostic Criteria
AD dementiaa
  • Progressive, insidious decline with dementia-level impairment

  • Amnestic or nonamnestic presentation
    • Amnestic (most common): impairment in learning and episodic memory
    • Nonamnestic: language (particularly word finding), visuospatial, or executive function
  • Not better explained by another entity

  • Can increase certainty with imaging or CSF biomarkers

Behavioral variant frontotemporal dementiab
  • Progressive cognitive and/or behavioral decline

  • Need 3 of the following:
    • Behavioral disinhibition
    • Apathy or inertia
    • Compulsive, ritualistic, or perseverative behavior
    • Hyperorality
    • Dysexecutive presentation with relative sparing of memory and visuospatial function
  • Can increase certainty with imaging biomarkers

DLBc
  • Progressive cognitive decline with dementia-level impairment

  • Core clinical features:
    • Fluctuating cognition
    • Well-formed visual hallucinations
    • RBD
    • Parkinsonism
  • Supportive features: sensitivity to antipsychotics, postural instability, falls, dysautonomia, delusions, anxiety, apathy, depression

  • Probable DLB: 2 core features or 1 core feature plus 1 indicative biomarker

  • Possible DLB: 1 core feature or 1 indicative biomarker

Abbreviation: CSF, cerebrospinal fluid.

a

Data from McKhann, G. M., Knopman D.S., Chertkow H., et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 7(3): 263-269.

b

Data from Rascovsky K., Hodges J.R., Knopman D., et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 134(Pt 9): 2456-2477.

c

Data from McKeith I. G., Boeve B.F., Dickson D.W., et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017 89(1): 88-100.