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. 2020 Aug 10;196:38–51. doi: 10.1016/j.thromres.2020.08.017

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© 2020 Published by Elsevier Ltd.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Progression to overt DIC in patients with fatal COVID-19.

Timeline charts illustrate the changes in coagulation parameters in 183 patients with COVID-19 pneumonia (21 non-survivors, 162 survivors). The error bars show medians and 25% and 75% percentiles. The horizontal lines show the upper normal limits of prothrombin time (PT) and d-dimer, and the lower normal limits of fibrinogen and antithrombin activity.

^aP < 0.05 for survivors versus non-survivors.

Reprinted from [38], with revisions, with permission.