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. 2020 Aug 10;13(4):313–329. doi: 10.1007/s12195-020-00642-z

Figure 4.

Figure 4

Viral magnetic lab-on-chip sensors. Magnetic nanoparticle technology for viral detection. (a) A schematic representation of the pcMNP-based SARS-CoV-2 viral RNA extraction method proposed by Zhao et al.90 A poly (amino ester) with carboxyl groups (PC) polymer was synthesized and used to coat magnetic nanoparticles to yield pcMNPs. (b) This method combines the lysis and binding steps into one step, and the pcMNPs-RNA complexes can be directly introduced into subsequent RT-PCR reactions. Permission has been requested from the author. (c) In a method proposed by Perez et al.,50 self-assembly of functionalized magnetic particles in the presence of viral particles could be measured via changes in water T2 relaxation times. Reprinted with permissions from J. Am. Chem. Soc. 2003, 125, 34, 10192–10193. Copyright 2003 American Chemical Society. (d) Peng et al.49 introduced a dual-modality immunoassay using fluorescent-magnetic-catalytic nanospheres (FMCNs) functionalized with antibodies to capture H9N2 avian influenza virus antigen, giving both a fluorescence and amplified electrochemical readout. Reprinted with permissions from ACS Appl. Mater. Interfaces 2019, 11, 44, 41148–41156. Copyright 2019 American Chemical Society.