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Splenic CD8 T cells from diet-induced obese (DIO) mice have increased spare respiratory capacity and greater glycolytic response relative to T cells from age- and diet-matched obese-resistant (OB-Res) mice. (A) Oxygen consumption rate (OCR, an indicator of OXPHOS) and (B) extracellular acidification rate (ECAR, an indicator of glycolysis) were assessed via examination of isolated CD8 T cells from naive OB-Res (n = 3) and DIO (n = 2) mice
