The metaorganismal metabolite phenylacetylglumatine (PAG) is derived from microbial metabolism of phenylalanine, and is involved in enhancement of platelet thrombotic potential via adrenergic receptors. ADP, adenosine diphosphate; α2A, α2A adrenergic receptor; α2B, α2B adrenergic receptor; β2, β2 adrenergic receptor; GPVI, Glycoprotein VI; IP3, inositol 1,4,5-triphosphate; P2Y12, purinergic receptor P2Y12,; PAR-1, Protease-activated receptor 1; PIP3, phosphatidylinositol trisphosphate, and PLC, phospholipase C.