Table 2. Age and hemoglobin adjusted association between serum albumin and sickle cell clinical variables in adults with sickle cell disease in validation cohort (OMG).
| Adjusted mean (SE) or beta (SE) | P value1 | |
|---|---|---|
| Female gender | F = 41.3 (0.27), M = 41.6 (0.29) | 0.39 |
| SS genotype | SS/SB0 = 41.4 (0.21), other = 41.4 (0.66) | 0.99 |
| Hospitalizations for severe pain in last year | 0–1 = 41.7 (0.27), | 0.036 |
| 2–4 = 40.5 (0.40), | ||
| >4 = 41.7 (0.50) | ||
| Chronic transfusion | N = 41.3 (0.21), Y = 41.3 (0.80) | 0.97 |
| History of acute chest syndrome | N = 41.6 (0.39), Y = 41.2 (0.24) | 0.41 |
| Leg ulcer | N = 41.5 (0.24), Y = 41.0 (0.44) | 0.33 |
| BMI (kg/m2) | -0.064 (0.037) | 0.08 |
| Current MCV (fL) | -0.019 (0.014) | 0.18 |
| Current WBC (x109/L) | 0.10 (0.05) | 0.040 |
| Current Platelet (x109/L) | -0.002 (0.001) | 0.10 |
| Lactate dehydrogenase (U/L) | -0.0007 (0.001) | 0.49 |
| Reticulocyte count (x109/L) | 0.001 (0.002) | 0.53 |
| Total bilirubin (mg/dL) | 0.20 (0.08) | 0.009 |
| Alanine aminotransferase (U/L) | -0.015 (0.007) | 0.049 |
| Aspartate aminotransferase (U/L) | -0.013 (0.006) | 0.022 |
| Alkaline phosphatase (U/L) | -0.006 (0.003) | 0.08 |
| Creatinine (mg/dL) | -0.37 (0.20) | 0.07 |
| eGFR (mL/min/1.73m2) | 0.021 (0.006) | <0.001 |
| NT-proBNP (pg/mL) | -0.0003 (0.0011) | 0.78 |
| Tricuspid regurgitation velocity (m/sec) | -0.65 (0.39) | 0.10 |
1 P values ≤ 0.001 are significant after correcting for multiple hypothesis testing using False Discover Rate <0.05.