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. 2020 Aug 10;15(8):e0237404. doi: 10.1371/journal.pone.0237404

Fig 1. Inflammation after RSV A2 infection.

Fig 1

1a. The semi-quantitative scoring of inflammation in lung sections of uninfected cotton rats, cotton rats 5 and 4 days post-RSV infection, and HDM-sensitized cotton rats was compared. The mean and standard deviations are represented (n = 4/ group). Asterisks indicate a p value < 0.05 by One-Way ANOVA. 1b. The total white blood cells per μL of bronchoalveolar lavage fluid (WBC/BALF) were compared between uninfected cotton rats, 5 days post-RSV infected cotton rats, or HDM sensitized cotton rats. Individual points represent the mean WBC/BALF from one animal with the mean and standard deviations represented too; 19DPI AAV-GFP (n = 3), 19DPI AAV-G (n = 3), 5DPI RSV (n = 4). Astericks indicate a p value < 0.05 by One-Way ANOVA. 1c. An H&E stain of an uninfected cotton rat lung representative of no to minimal inflammation. 1d. An H&E stain of a 4dpiRSV cotton rat lung representative of mild inflammation characterized by small numbers of peribronchiolar and perivascular lymphocytes and histiocytes. 1e. An H&E stain of a HDM sensitized cotton rat lung representative of moderate inflammation characterized by many peribronchiolar and perivascular lymphocytes and histiocytes, and numerous granulocytes within alveolar septae (interstitial infiltrates), abundant macrophages and granulocytes within alveoli, and many granulocytes within bronchiolar epithelium.