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. 2020 Aug 4;11:1719. doi: 10.3389/fimmu.2020.01719

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Copyright © 2020 Locke, Schlesinger and Crouser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Key immune cell populations are represented in the in vitro human granuloma model. (A) Immunofluorescence microscopy image showing CD11b⁺ macrophages and CD3⁺ lymphocytes are present in a representative granuloma-like structure formed by M.tb. antigen-simulated PBMCs from a M.tb. naïve sarcoidosis patient. The image is a composite of 3 fluorescent channels: blue, yellow, and cyan channels represent the M.tb. antigen-coated beads, CD11b staining, and CD3 staining, respectively. (B) A differential interference contrast image of the same granuloma-like structure.