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. 2020 Aug 4;14:72. doi: 10.3389/fncom.2020.00072

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Copyright © 2020 Bingham, Paknahad, Girard, Loizos, Bouteiller, Song, Lazzi and Berger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A 2-D rendering of the biologically realistic NEURON model of a rodent dentate gyrus with demarcation of recording and stimulating devices. (B) The slice model is populated with 10 k entorhinal cortical axons which synapse with 50 k granule cells. The entire model comprises ≈12.25 million synapses and ≈15 million neuronal compartments. (C) The NEURON model was imbedded in a meshed volume with bipolar stimulating electrodes targeting the perforant pathway. (D) Analytical estimates of LFPs corresponded well with in vitro MEA recordings in temporal dynamics and waveform. Model validation was performed for stimulation at the crest perforant path and recordings from the suprapyramidal cell body layer. Details regarding the construction and application of this model are described at length in Bingham et al. (2018a).