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Observed and predicted probabilities of worst adverse event grades for the safety and tolerability endpoints. Probabilities of worst grade adverse events for a neutropenia (n = 23 patients), b increased ALT (n = 15), c increased AST (n = 13), d hypertension (n = 10), (E) lymphopenia (n = 16), f thrombocytopenia (n = 13), g leukopenia (n = 20), h fatigue (n = 24), i nausea (n = 7), and j vomiting (n = 7). ALT alanine transaminase, AST aspartate transaminase
