Table 1.

CTCAE criteria for toxicity in hypersensitivity reactions.

Grade	Reaction
1	Transient erythema or rash fever <38C; intervention not indicated
2	Intervention or interruption of the infusion are indicated; respons quickly to symptomatic treatment (e.g.: antihistamines, NSAID’s, opioids, etc.); prophylactic drugs indicated <24 h
3	Extended (e.g., do not respond quicly to symptomatic medication andor a brief interruption of the infusion); recurrence of symptons after initial improvement; hospitalization indicated by clinical sequelae (e.g., renal failure, pulmonary infiltrates)
4	Life threatening episodes: urgent intervention indicated
5	Death

Source: Barba et al.¹⁴.