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The movement of UBL in CoV2 allows for interactions between UBL residue Pro59 and the thumb domain residues Thr75 and Pro77. These interactions subsequently result in different rotameric states for the nearby key Ub-interacting residue Phe69/Phe70 in CoV2/CoV1. Green arrow indicates the major motion of UBL; green circle indicates SUb2.
