Table 1.

Inclusion and exclusion criteria.

Inclusion criteria

Positive analysis by real-time reverse transcriptase-polymer chain reaction [RT PCR (Shanghai BioTec or Sansure Biotech)] for SARS-CoV-2 of pharyngeal and nasal swabs

Non-pregnant male or female sex, aged 18 and over imaging [thoracic ultrasound, chest X Ray (CXR) or computed axial tomography (CT scan) positive for pneumonia]

Oxygen saturation (SaO2) of 93% or less in on room air

Ratio of partial oxygen pressure (PaO2) to inspired oxygen fraction (FiO2) (PaO2/FiO2) less than 200 mg/Hg but not less than 100

Rapid clinical evolution with worsening respiratory parameters in the last 12 h

Exclusion criteria

Known hypersensitivity to the drugs

Patients in assisted breathing with tracheal cannula

Patients with active and undetailed serious illnesses prior to COVID-19 infection

Patients with kidney failure

Patients with positive Quantiferon TB test

Patients with unchecked documented bacterial or fungal sepsis (excluding procalcitonin in the presence of negative hemocultures)

Patients with neutropenia of 1,000 neutrophils/μl or less

Patients with platelets of 100,000/μl or less