FIGURE 2.

Increased resting power was observed in Fmr1 KO mice compared to WT mice in the pre-drug condition. After mice were habituated to the recording area, 5 min resting EEG was recorded in the absence of any overt sensory stimulation. Mean power density was calculated for both genotypes using both auditory and frontal cortex electrodes (A,C). For statistical comparisons, average power in each frequency band (color) was compared using standard frequency cutoffs (B, D). Statistical comparisons are the result of MANCOVA, using the % movement for individual animals as a covariate, in order to isolate genotype effects from potential hyperactivity phenotypes. In general, Fmr1 KO mice showed an increase in raw power, but the most statistically robust differences were in the low and high gamma band ranges. p-values were corrected for multiple comparisons using Bonferroni procedures, and each brain region was run separately (23 Fmr1 KO mice and 21 WT mice; *p < 0.05, **p < 0.01, ***p < 0.001, ^#p < 0.00001).