FIGURE 3.

Minocycline treatment reduces resting gamma power in Fmr1 KO mice to WT levels. After Fmr1 KO mice were treated for 10 days with minocycline, mean power density was calculated for both groups using both auditory and frontal cortex electrodes (A,C). The most significant phenotypes in the gamma frequency range were normalized and resting gamma power was similar to WT (Veh) treatment group (B,D). Lower frequency deficits were still present (12 minocycline KO and 12 vehicle WT; *p < 0.05, ***p < 0.01, ****p < 0.001, *****p < 0.0001, ^#p < 0.00001).