FIGURE 4.

Minocycline effects on gamma power were no different from vehicle effects in the Fmr1 KO mice. The 10-day minocycline effectiveness was compared against a 10-day vehicle treated group in Fmr1 KO mice. Mean power density was calculated for both drug conditions using both auditory and frontal cortex electrodes (A,C). No statistical significance was observed on this measure for KO mice (B,D). Minocycline is not better or worse than a vehicle control on resting EEG power spectral density (12 minocycline KO and 11 vehicle KO; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ^#p < 0.00001).