FIGURE 5.

Minocycline reverses phase locking deficits tested with chirp stimuli. (A–F) Colored regions are group mean differences between different genotype and drug conditions. Black-outlined regions are significantly reduced (blue with solid black outline) or increased (red with dotted black outline) as a result of a statistical permutation approach. (A, D) In the AC, there is a decrease in ITPC at beta to low-gamma bands, and an increase in ITPC in the high gamma range in the Fmr1 KO mice. In the FC, there is a decrease in ITPC between beta to high gamma frequencies. (B, E) Ten days of minocycline treatment increases ITPC in Fmr1 KO mice compared to vehicle in the FC, but not in the AC, suggesting a differential response of the two regions to this treatment. (C, F) The normalizing effect of minocycline in Fmr1 KO mice can be seen. In both the AC and FC, there is no difference between the minocycline treated KO and vehicle treated WT groups at beta/low-gamma bands.