FIGURE 6.

Minocycline reverses phase locking deficits in the 40 Hz ASSR in the FC. An auditory steady state response is the response to a series of 40 Hz train of clicks (1 s duration). The analysis and interpretation are the same as in Figure 5. Comparing genotype differences in ITPC before drug treatment reveals a robust reduction in the Fmr1 KO mice compared to WT in the FC (D), but not in the AC (A). After treating KO mice with minocycline for 10 days, ITPC values in the FC increased significantly compared to vehicle-treated controls in matching time x frequency regions (E), with no effect in the AC (B). Direct comparison of ASSR in Fmr1 KO mice treated with minocycline to vehicle-treated WT mice show virtually no difference, suggesting a rescue of the phenotype in the FC (F), and again no effect found in the AC (C).