FIGURE 7.

Minocycline reduces sound-induced gamma power in Fmr1 KO mice. Trains of 100 ms duration broad band noise were used to generate event related potentials (200 repetitions) for time × frequency analyses. After correcting for baseline (–250 ms through –150 ms) single trial power was averaged over all trials. This allows for the analysis of power that is normalized to individual animal baselines. In the pre-drug condition, Fmr1 KO mice showed increased on-going power after the auditory stimulus in the delta and high gamma range in both AC and FC (A,D). In addition, the FC showed a significant reduction in power the beta to low gamma frequency range (D). Minocycline treatment significantly reduced onset power in Fmr1 KO animals over vehicle treatment in both FC and AC (B,E), but also increased power in the AC in two distinct bands at ∼20 and ∼40 Hz that occurred well after sound onset. Finally, comparing minocycline treated Fmr1 KO mice to vehicle-treated WT group, reveals a shift in power in AC from high gamma in (A), to low gamma in (C). Additionally in the FC, ongoing gamma power and modulation of beta – low gamma power in (D) are significantly reduced (F).