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. 2020 Aug 10;10:13484. doi: 10.1038/s41598-020-70321-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dosing time-dependent change in L-OHP-induced leukopenia in mice. (a) Schematic experimental procedure for evaluating the dosing time dependency of L-OHP-induced leukopenia. Mice were injected with L-OHP (20 mg/kg, i.v.) or saline at ZT6 and ZT18. The number of peripheral WBCs was assessed from 72 to 92 h (4-h intervals) after L-OHP injection. (b) Temporal profiles of the number of peripheral WBCs in mice after injecting L-OHP (20 mg/kg, i.v.) or saline at ZT6 (left) or ZT18 (right). The horizontal bar at the bottom indicates the light and dark cycles. Values are the mean with S.D. (n = 6). **P < 0.01, *P < 0.05, significant difference from the saline-injected group at the corresponding time point. (c) Comparison of the value of AUC_72–92 in the number of peripheral WBCs after injecting L-OHP (20 mg/kg, i.v.) or saline at ZT6 or ZT18. Values are the mean with S.D. (n = 6). **P < 0.01, significant difference between the two groups.