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. 2020 Aug 4;14:227. doi: 10.3389/fncel.2020.00227

Figure 4.

Figure 4

Altered paw angle and rate of deceleration during the braking phase in naïve ngr1−/− mice. For detailed methods please see the Supplementary Information. (A) Absolute paw angle is the angle that the paw makes with the long axis of the direction of motion (midline). Higher absolute paw angles represent greater degrees of external rotation. (B) The forepaws of naïve NgR1-KO (ngr1−/−) mice are less externally rotated than naïve wildtype mice (ngr1+/+), while NgR1-KO hind paws are more externally rotated than WT mice. (C) The maximal rate of change of the paw area (MAX dA/dT) provides a measure of how rapidly the animal decelerates during the braking phase. An increased MAX dA/dT represents a greater change in paw area over the same amount of time; therefore, compared to its littermate (i), the animal is placing its paw down faster (ii; modified from Vincelette et al., 2007). (D) KO mice had an increased MAX dA/dT compared to WT mice for both fore- and hind-paws. Data are presented as mean ± SEM. Unpaired t-test. *P < 0.05, **P < 0.01, ****P < 0.0001.