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In vivo osteogenic performance: (a, b) 3D images reconstructed by micro-CT in Ti and NS4 implants; (b1-b3) 2D micro-CT images of NS4implants in tibia; (c) Quantitative analysis of bone volume/total volume (BV/TV) around the implants calculated from the micro-CT(**p < 0.01); (d) Safranin-O/Fast Green staining of the tissue around the implantsafter 1month implantation; (e) Methylene Blue-Acid Fuchsin staining of the tissue around the implantsafter 1month implantation.
