Table 5.
Up-regulated lncRNAs in endometriosis.
| lncRNA | Species | Numbers of clinical samples | Assessed cell line | Targets/Regulators | Signaling Pathways | Function | References |
|---|---|---|---|---|---|---|---|
| TC0101441 | Human | 10 pairs of ectopic and eutopic endometria from patients with ovarian endometriotic cysts, normal endometrium tissue (n = 10) | ECSCs | N-cadherin, snail, slug, TCF8/ZEB1 | – | Extracellular vesicle-mediated transfer of the lncRNA-TC0101441 could enhance the migration and invasion of endometriosis | (77) |
| UCA1 | Human | 98 patients with endometriosis, 28 normal controls (serum samples) | – | – | – | LncRNA-UCA1 could be used as a diagnostic and prognostic biomarker for ovarian endometriosis | (76) |
| MALAT1 | Human | Endometrial tissues from patients with endometriosis (n = 15), normal controls (n = 7) | Endometrial cells | MMP-9, caspase-3 | NF-κB/iNOS | LncRNA-MALAT1 via NF-κB/iNOS pathway could facilitate endometrial cell apoptosis and also via targeting MMP-9 could suppress endometrial cell proliferation and invasion. | (78) |
| Human | Paired eutopic and ectopic endometrium samples from patients with endometriotic (n = 30), normal controls (n = 30) | HESCs | HIF-1α, 3-MA, Beclin1 | – | LncRNA-MALAT1 via targeting HIF-1α/3-MA/Beclin1 could mediate hypoxia-induced pro-survival autophagy of HESCs in endometriosis. | (79) | |
| CCDC144NL-AS1 | Human | Paired ectopic and eutopic endometria from patients with endometriotic (n = 34), normal controls (n = 27) | hEM15A, HUVECs | Vimentin, MMP-9 | – | lncRNA-CCDC144NL-AS1 knockdown could decrease migration and invasion phenotypes in endometrial stromal cells from endometriosis | (80) |
| BANCR | Rat | – | – | VEGF, MMP-2, MMP-9 | ERK/MAPK | lncRNA-BANCR inhibitor via inhibiting ERK/MAPK signaling pathway could repress the development of ectopic endometrial tissues | (81) |
| SNORD3A, TCONS_00006582 | Human | Eutopic endometrium samples (n = 17), normal samples (n = 17) | – | – | – | lncRNAs could be considered as novel diagnostic biomarkers and therapeutic targets for endometriosis | (82) |
| NONRATT006252, gi|672027621|ref|XR_592747.1|, gi|672045999|ref|XR_591544.1|, gi|672066614|ref|XR_594547.1, NONRATT006252, gi|672045999|ref|XR_591544.1| | Rat | – | – | Dlx3, P2ry6, Adamts7 | – | During the implantation window process, changes in the expression of lncRNAs could affect endometrial receptivity in rats with endometriosis. | (74) |
| AFAP1-AS1 | Human, mouse | Paired eutopic and ectopic endometrium samples from patients with ovarian endometriotic cysts (n = 18), normal controls (n = 10) | HESCs, ISK | ZEB1, E-cadherin | – | lncRNA-AFAP1-AS1 by targeting ZEB1 could promote EMT of endometriosis. Knockdown of AFAP1-AS1 could inhibit the growth of endometrial epithelial cells through inhibiting E2-induced activity of promoter site pGL3-P886 of transcription factor ZTB1. | (83) |
| LINC01279, MSC-AS1 | Human | GSE7305, GSE7846, GSE29981 and E-MTAB-694 datasets | – | – | – | LINC01279 and MSC AS1 could be associated with the pathogenesis of endometriosis. | (84) |
| CHL1-AS2 | Human | Paired eutopic and ectopic endometrium samples from patients with endometriotic (n = 31), normal controls (n = 30) | HL-60, Jurkat | – | – | lncRNA-CHL1-AS2 could be involved in the endometriosis development. | (85) |
| H19 | Human | Eutopic endometrial tissues from patients with endometriosis (n = 23), normal controls (n = 23) | HESCs, 293T | miR-216a-5p, ACTA2 | – | The estrogen-regulated lncRNA-H19/ACTA2/miR-216a-5p axis could mediate the invasion and migration of eutopic endometrial stromal cells (euESCs) in women with endometriosis. | (78) |
| HOXA11-AS1 | Human | Paired eutopic and ectopic endometrium samples from patients with endometriotic (n = 30), normal controls (n = 15) | – | HOXA9, HOXA10, HOXA11, HOXA13 | Although lncRNA-HOXA11-AS1 had no role on endometrial receptivity in endometriosis-associated infertility, it could influence the development of peritoneal endometriosis. | (86) | |
| AC068282.3, RP11-369C8.1, RP11-432J24.5, GBP1P1 | Human | Eutopic endometrial tissues from patients with endometriosis (n = 40), normal controls (n = 28) | – | – | – | lncRNAs could be considered as novel diagnostic biomarkers and therapeutic targets for endometriosis. | (87) |
| CHL1-AS2, XLOC_009813, LOC643650, XLOC_009813, LOC255167, LOC400043, XLOC_012904, XLOC_l2_009510, AFAP1-AS1, XR_113107, XLOC_002900, LOC284576, XLOC_002900, XLOC_004907, XLOC_009813, XLOC_l2_008976, XLOC_006043, LOC100128893, XLOC_002900, XR_110229 | Human | Paired eutopic and ectopic endometrium samples from patients with endometriotic (n = 25) | – | – | – | lncRNAs could be considered as novel diagnostic biomarkers and therapeutic targets for endometriosis. | (75) |
| PRKAR2B | Human | Paired eutopic and ectopic endometrium samples from patients with endometriotic (n = 3), normal controls (n = 3) | – | – | PI3K-Akt, NF-κB, TGF-β, MAPK | lncRNA could be considered as a novel diagnostic biomarker and therapeutic target for endometriosis. | (88) |
| NONHAT076754 | Human | Paired eutopic and ectopic endometrium samples from patients with ovarian endometriotic cysts (n = 92) | HESCs | ZO-1, E-cadherin, N-cadherin | – | Exosomal lncRNA-NONHAT076754 could facilitate endometriosis invasion. | (89) |
| aHIF | Human | Ectopic (n = 30) and normal (n = 16) endometrium samples | ECSCs, HUVECs | VEGF-A, VEGF-D | – | Exosomal lncRNA-aHIF could Promote angiogenesis in endometriosis. | (90) |