FIGURE 5.

F9 and TSP-1 were verified by ELISA in expanded sample sizes. ROC curves for exosomal proteins that are significantly different in epilepsy patients compared to healthy controls. (A) ELISA shows concentrations of F9 (a) and TSP-1 (b) in serum exosomes in different groups. Mann-Whitney U test was performed, n = 200 for each group, ^****P < 0.0001. (B,C) ROC curves for exosomal F9 and TSP-1 were used to discriminate epilepsy patients and healthy controls, and the area under the ROC curve (AUC) was used to evaluate the level of discrimination.