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. 2020 Aug 4;14:51. doi: 10.3389/fnsys.2020.00051

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Copyright © 2020 Yang, Zhan, Lin, Chu, Qiu and Lan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of fentanyl on-air puff-evoked responses in cerebellar Purkinje cells (PCs). (A) Excitatory inputs coming from parallel fibers (PFs) and inhibitory inputs coming from the molecular layer interneurons (MLIs) innervate PCs. (B) Upper, representative cell-attached recording from a PC showing responses to air-puff stimulation (60 ms, 60 psi) in artificial cerebrospinal fluid (ACSF), fentanyl (5 μM) and washout; lower, enlarged traces from the upper panel showing the effect of fentanyl on sensory-evoked responses. (C) Summary of data (n = 6) showing the time course of 5 μM fentanyl-induced changes in the amplitude of P1. (D,E) Pooled data showing the normalized pause (D) and frequency (E) of a simple spike (SS) in ACSF, fentanyl (5 μM), and washout. (F,G) The bar graph shows the effects of fentanyl (5 μM) on the normalized amplitude (E) and area under the curve (AUC, G) of P1. *P < 0.05 vs. ACSF group.