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. 2020 Aug 4;14:51. doi: 10.3389/fnsys.2020.00051

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Copyright © 2020 Yang, Zhan, Lin, Chu, Qiu and Lan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protein kinase A blocker, H-89 partially prevented the fentanyl-induced inhibition of P1 in cerebellar PCs. (A) Upper, an example of cell-attached recording from a PC showing responses to facial stimulation (60 ms, 60 psi) in control fentanyl (5 μM) and washout in the presence of H-89; lower, enlarged image from the upper panel showing the effects of fentanyl on air-puff stimulation-evoked responses in the presence of H-89. (B) Summarized results showing the time course of 5 μM fentanyl-induced changes in the amplitude of P1 in the presence of H-89 (n = 6). (C,D) Summarized data showing the normalized pause (C) and frequency (D) of simple spikes (SSs) in control, fentanyl (5 μM), and washout in the presence of H-89. (E,F) Bar graph showing the effects of fentanyl (5 μM) on the normalized amplitude (E) and area under the curve (AUC) (F) of P1 in the presence of H-89. *P < 0.05 vs. control group.